{"id":9999,"date":"2018-06-29T17:57:42","date_gmt":"2018-06-29T15:57:42","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=9999"},"modified":"2018-07-03T20:00:53","modified_gmt":"2018-07-03T18:00:53","slug":"abbvie-dumps-galapagos-cystic-fibrosis-combo","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/abbvie-dumps-galapagos-cystic-fibrosis-combo\/","title":{"rendered":"AbbVie dumps Galapagos\u2019 cystic fibrosis combo"},"content":{"rendered":"

AbbVie has\u00a0dumped<\/a>\u00a0one of Galapagos\u2019 cystic fibrosis regimens after getting a look at underwhelming clinical data on a component of the triple combination. The action prompted Galapagos to review the future of its relationship with AbbVie\u2014and provided a boost to cystic fibrosis rival Vertex.<\/p>\n

Galapagos has moved one AbbVie-partnered triple combination into clinical development but hopes are higher for the follow-up regimen, which features a potentiator with a shorter metabolite half-life. Despite that, AbbVie has decided against proceeding with the second, more-promising combination after reviewing data on the C2 corrector, GLPG2737, that features in both regimens.<\/p>\n

Investigators enrolled 22 cystic fibrosis patients who were homozygous for Class II F508del mutation and on stable treatment with Vertex\u2019s Orkambi. Two-thirds of participants received GLPG2737 on top of Orkambi, while the rest received placebo plus Vertex\u2019s drug.<\/p>\n

The trial met its primary, sweat chloride concentration endpoint but failed against a measure of lung function. Notably, the percentage change in the ppFEV1 measure of lung function\u20143.4%\u2014came in below the 5% targeted by analysts and well under the 7% to 13% improvements achieved by Vertex\u2019s triple combinations. Using a higher dose of GLPG2737 and pairing it with Galapagos\u2019 drugs, not Orkambi, could give the triple combinations better efficacy but for now Vertex looks to have an edge.<\/p>\n

Vertex\u2019s combinations are further down the pipeline, too, meaning Galapagos faces the prospect of trying to come from behind with what may prove to be a less efficacious therapy.<\/p>\n

\u201cThe key is Vertex sees robust and rapid effects with all of their combos and is already well into phase 3 with at least two\u2014and Galapagos has not put out much triple data thus far,\u201d Jefferies analyst Michael Yee wrote in a note to investors.<\/p>\n

Galapagos may have to tackle the challenge without AbbVie. For now, AbbVie remains partnered on the first triple combination. But Galapagos is reviewing the broader cystic fibrosis partnership in light of AbbVie\u2019s decision to drop the second triple combination.<\/p>\n

AbbVie\u2019s decision further complicates one of the more fractious partnerships in biotech. Three years ago, AbbVie dumped Galapagos\u2019 JAK inhibitor filgotinib and switched focus to its rival drug, leaving its one-time partner trailing in the race to market. The existing cystic fibrosis partnership continued but there have been signs of tension. According to Dutch newspaper Het Financieele Dagblad, Galapagos CEO Onno van de Stolpe\u00a0thinks<\/a>\u00a0AbbVie is to blame for delays to the cystic fibrosis program and that it would advance just as well without the Big Pharma.<\/p>\n

Galapagos may now get a chance to find out whether van de Stolpe is right.<\/p>\n

Source: FierceBiotech<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

AbbVie has\u00a0dumped\u00a0one of Galapagos\u2019 cystic fibrosis regimens after getting a look at underwhelming clinical data on a component of the triple combination. The action prompted Galapagos to review the future of its relationship with AbbVie\u2014and provided a boost to cystic fibrosis rival Vertex. Galapagos has moved one AbbVie-partnered triple combination into clinical development but hopes […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39,43],"tags":[],"class_list":["post-9999","post","type-post","status-publish","format-standard","hentry","category-gezondheid","category-innovatieklimaat"],"acf":[],"yoast_head":"\nAbbVie dumps Galapagos\u2019 cystic fibrosis combo - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/abbvie-dumps-galapagos-cystic-fibrosis-combo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AbbVie dumps Galapagos\u2019 cystic fibrosis combo - hollandbio\" \/>\n<meta property=\"og:description\" content=\"AbbVie has\u00a0dumped\u00a0one of Galapagos\u2019 cystic fibrosis regimens after getting a look at underwhelming clinical data on a component of the triple combination. 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