{"id":23341,"date":"2023-03-14T13:51:14","date_gmt":"2023-03-14T12:51:14","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=23341"},"modified":"2023-03-14T13:54:23","modified_gmt":"2023-03-14T12:54:23","slug":"treeway-announces-first-patient-enrolled-in-the-phase-2a-asure-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/treeway-announces-first-patient-enrolled-in-the-phase-2a-asure-clinical-trial\/","title":{"rendered":"Treeway announces first patient enrolled in the Phase 2a ASURE clinical trial"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Treeway, in collaboration with the Alzheimer Drug Discovery Foundation (ADDF), announced today the successful enrollment of the first patient in the Alzheimer\u2019s Disease Study Using Oral Edaravone (ASURE), Phase 2a clinical trial. The trial will include 60 patients in different European countries, and will evaluate the safety, pharmacodynamics and pharmacokinetics of oral edaravone in Alzheimer\u2019s patients. This is the first clinical study that aims to investigate the effect of oral edaravone, a novel multimodal treatment for early onset of Alzheimer\u2019s Disease (AD).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe are thrilled to venture into a clinical phase for Alzheimer\u2019s Disease, building on our experience in neurodegenerative disease and inspired by patients. Our team is passionately working on advancing oral edaravone as a potential treatment for AD,\u201d said Inez de Greef, Chief Executive Officer at Treeway. AD is a complex disease where multiple disease pathways occur in parallel. Despite recent positive results in the field, there is still a high need to counter AD progression in multiple disease domains. Edaravone is a free radical scavenger and acts by reducing oxidative stress, which plays a pivotal role in the development and progression of the disease. Moreover, edaravone has been shown to modulate mitochondrial dysfunction and pathological neuroimmune processes in AD animal<br>models.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to Dr. Jort Vijverberg, Neurologist and Principal Investigator of the trial: \u201cWe are confident that this study will provide us with important information about Alzheimer\u2019s disease as we will be monitoring multiple important pathophysiological mechanisms throughout the study.\u201d The innovative trial design, which includes a panel of biomarkers, novel EEG markers and cognitive functioning outcomes, will investigate the potential of oral edaravone in treating AD. Ronald van der Geest, Treeway\u2019s Chief Development Officer added: \u201cWe are excited to be enabled by ADDF to extent our activities to Alzheimer\u2019s and to collaborate with one of the top centers in the world. With the help of the Amsterdam team, we believe we have incorporated the latest insights in AD trial design into our study.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Treeway, in collaboration with the Alzheimer Drug Discovery Foundation (ADDF), announced today the successful enrollment of the first patient in the Alzheimer\u2019s Disease Study Using Oral Edaravone (ASURE), Phase 2a clinical trial. The trial will include 60 patients in different European countries, and will evaluate the safety, pharmacodynamics and pharmacokinetics of oral edaravone in Alzheimer\u2019s [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-23341","post","type-post","status-publish","format-standard","hentry","category-gezondheid"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Treeway announces first patient enrolled in the Phase 2a ASURE clinical trial - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/treeway-announces-first-patient-enrolled-in-the-phase-2a-asure-clinical-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Treeway announces first patient enrolled in the Phase 2a ASURE clinical trial - hollandbio\" \/>\n<meta property=\"og:description\" content=\"Treeway, in collaboration with the Alzheimer Drug Discovery Foundation (ADDF), announced today the successful enrollment of the first patient in the Alzheimer\u2019s Disease Study Using Oral Edaravone (ASURE), Phase 2a clinical trial. 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