{"id":19454,"date":"2021-05-04T15:49:01","date_gmt":"2021-05-04T13:49:01","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=19454"},"modified":"2021-05-04T15:49:02","modified_gmt":"2021-05-04T13:49:02","slug":"toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/","title":{"rendered":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Testing for developmental toxicity according to the current international guidelines requires large numbers of animals, making these tests very resource-intensive and time-consuming as well as raising ethical concerns. The current ReproTracker <em>in vitro<\/em> teratogenicity assay has been available to clients since 2020 and monitors the differentiation of stem cells into functional heart, liver and neural tissues. The assay has been validated using various reference compound libraries and has shown a high predictivity for the detection of <em>in vivo<\/em> teratogenic compounds. Consequently, ReproTracker allows a much more rapid and cost-effective developmental toxicity hazard identification for novel and existing drugs, chemicals, and many other substances.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this collaborative project between Toxys and Unilever, the ReproTracker assay will be further validated with various classes of reference compounds. Importantly, quantitative dose-response models will be developed for the ReproTracker biomarkers to define the developmental toxicity of test agents at doses that are relevant for human exposure. Furthermore, optimised and validated protocols will be developed for human induced pluripotent stem cell (hiPSC) differentiation into bone cells (osteoblasts) as a new and valuable endpoint within ReproTracker to cover skeletal developmental toxicity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The intent of the collaboration with Unilever is to extend and further validate ReproTracker in order to design a teratogenicity strategy in line with the next generation risk assessment (NGRA) framework that integrates new approach methodologies (NAMs) to ensure product safety without generating animal data. Through this Unilever collaboration, and by adding in validated biomarkers for skeletal development, ReproTracker will be even better positioned to improve developmental toxicity testing without the use of animals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe are very happy to be starting this new initiative with Toxys to further build the ReproTracker capability for exposure-led <em>in vitro<\/em> developmental toxicity testing in NGRA. In recent times, Toxys have stood out as a developer and provider of data from innovative NAMs that underpin human- focused bioactivity point-of-departure determinations without pathology in animals. We anticipate a great synergy from our combined efforts to raise the bar in non-animal based safety assessments\u201d.<br>\u2013 Professor Paul Carmichael, Unilever SEAC<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe are very excited about the collaboration with Unilever to further validate and extend ReproTracker and further support the non-animal safety testing of novel chemicals, cosmetics and consumer products. Toxys is continuously looking for opportunities to expand and improve its portfolio of unique animal-free assays for chemical safety testing. With its long-standing expertise in non-animal human safety testing, Unilever SEAC is an ideal collaborator for Toxys.\u201d \u2013 Dr. Giel Hendriks, CEO of Toxys<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: Toxys (<a href=\"https:\/\/toxys.com\/blog\/2021\/04\/28\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/\">Press release<\/a>)<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay. Testing for developmental toxicity according to the current international guidelines requires large numbers of animals, making these tests very resource-intensive and time-consuming as well as raising ethical concerns. The current ReproTracker in vitro [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46,43],"tags":[],"class_list":["post-19454","post","type-post","status-publish","format-standard","hentry","category-voedsel-materialen","category-innovatieklimaat"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio\" \/>\n<meta property=\"og:description\" content=\"Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay. Testing for developmental toxicity according to the current international guidelines requires large numbers of animals, making these tests very resource-intensive and time-consuming as well as raising ethical concerns. The current ReproTracker in vitro [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/\" \/>\n<meta property=\"og:site_name\" content=\"hollandbio\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-04T13:49:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-04T13:49:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2025\/01\/hb-opengraph_illu.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"HollandBIO\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:site\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"HollandBIO\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/\"},\"author\":{\"name\":\"HollandBIO\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/person\\\/48824449f08e494bb7ea02e1ff5dd6ea\"},\"headline\":\"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment\",\"datePublished\":\"2021-05-04T13:49:01+00:00\",\"dateModified\":\"2021-05-04T13:49:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/\"},\"wordCount\":450,\"publisher\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\"},\"articleSection\":[\"Voedsel en materialen\",\"Innovatieklimaat\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/\",\"name\":\"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#website\"},\"datePublished\":\"2021-05-04T13:49:01+00:00\",\"dateModified\":\"2021-05-04T13:49:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\",\"name\":\"hollandbio\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\",\"name\":\"hollandbio\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/HollandBIO_logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.hollandbio.nl\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/HollandBIO_logo.svg\",\"width\":218.664,\"height\":29.659,\"caption\":\"hollandbio\"},\"image\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/hollandbio\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/hollandbio\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/person\\\/48824449f08e494bb7ea02e1ff5dd6ea\",\"name\":\"HollandBIO\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/","og_locale":"en_US","og_type":"article","og_title":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio","og_description":"Toxys and Unilever Safety and Environmental Assurance Centre (SEAC) have entered into an agreement to further validate and expand the ReproTracker assay. Testing for developmental toxicity according to the current international guidelines requires large numbers of animals, making these tests very resource-intensive and time-consuming as well as raising ethical concerns. The current ReproTracker in vitro [&hellip;]","og_url":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/","og_site_name":"hollandbio","article_published_time":"2021-05-04T13:49:01+00:00","article_modified_time":"2021-05-04T13:49:02+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2025\/01\/hb-opengraph_illu.png","type":"image\/png"}],"author":"HollandBIO","twitter_card":"summary_large_image","twitter_creator":"@hollandbio","twitter_site":"@hollandbio","twitter_misc":{"Written by":"HollandBIO","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/#article","isPartOf":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/"},"author":{"name":"HollandBIO","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/person\/48824449f08e494bb7ea02e1ff5dd6ea"},"headline":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment","datePublished":"2021-05-04T13:49:01+00:00","dateModified":"2021-05-04T13:49:02+00:00","mainEntityOfPage":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/"},"wordCount":450,"publisher":{"@id":"https:\/\/www.hollandbio.nl\/en\/#organization"},"articleSection":["Voedsel en materialen","Innovatieklimaat"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/","url":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/","name":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment - hollandbio","isPartOf":{"@id":"https:\/\/www.hollandbio.nl\/en\/#website"},"datePublished":"2021-05-04T13:49:01+00:00","dateModified":"2021-05-04T13:49:02+00:00","breadcrumb":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/toxys-and-unilever-enter-agreement-to-further-validate-and-expand-reprotracker-for-animal-free-developmental-toxicity-assessment\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.hollandbio.nl\/en\/"},{"@type":"ListItem","position":2,"name":"Toxys and Unilever enter agreement to further validate and expand ReproTracker for animal- free developmental toxicity assessment"}]},{"@type":"WebSite","@id":"https:\/\/www.hollandbio.nl\/en\/#website","url":"https:\/\/www.hollandbio.nl\/en\/","name":"hollandbio","description":"","publisher":{"@id":"https:\/\/www.hollandbio.nl\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.hollandbio.nl\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.hollandbio.nl\/en\/#organization","name":"hollandbio","url":"https:\/\/www.hollandbio.nl\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2023\/08\/HollandBIO_logo.svg","contentUrl":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2023\/08\/HollandBIO_logo.svg","width":218.664,"height":29.659,"caption":"hollandbio"},"image":{"@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/hollandbio","https:\/\/www.linkedin.com\/company\/hollandbio\/"]},{"@type":"Person","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/person\/48824449f08e494bb7ea02e1ff5dd6ea","name":"HollandBIO"}]}},"_links":{"self":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts\/19454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/comments?post=19454"}],"version-history":[{"count":0,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts\/19454\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/media?parent=19454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/categories?post=19454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/tags?post=19454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}