{"id":18995,"date":"2021-02-16T14:37:25","date_gmt":"2021-02-16T13:37:25","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=18995"},"modified":"2021-02-16T14:37:26","modified_gmt":"2021-02-16T13:37:26","slug":"interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\/","title":{"rendered":"InteRNA Technologies Announces Dosing of First Patient in First-in-Human Trial of microRNA Drug Candidate INT-1B3 in Patients with Advanced Solid Tumors"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/r20.rs6.net\/tn.jsp?f=001M5Xu_IsFLzj2oN3mdz3V53tRNu5xk66YTYtVLgSSpHUtfhRPpR_1W__HqQvRQUZLSnkfPsbtNEnjW0-0InePXcx48XpaI8h8ZxzVFdiIgw_SxCJu3eixj-tBaZwmsBwkvbOsQdhaO5jMlMLCz5tOYt-r3Z37bOIS&amp;c=2Nmzju-GvmC-TZgVo6_dAx-QWd7pJ3EwwxajloM7DR53l-nZPsSlRQ==&amp;ch=xlHfkWxE4NHjp29M68pqxp6cDhp18rTOCS0XKYBAodtW9eti2_KTUQ==\" target=\"_blank\" rel=\"noreferrer noopener\">InteRNA Technologies<\/a> announced today that the first patient has been dosed in the first cohort of its first-in-human Phase I study with the Company\u2019s lead microRNA candidate, INT-1B3. The trial will evaluate safety and initial signs of efficacy of INT-1B3, a microRNA-mimic of the endogenous tumor suppressor miR-193a-3p formulated in next-generation lipid nanoparticles, in patients with advanced solid tumors. INT-1B3 represents a promising novel therapeutic approach that could address multiple hallmarks of cancer simultaneously by directly targeting tumor cells and the tumor microenvironment by specific modulation of multiple relevant signaling pathway components triggering a long-term T cell-mediated immune response against the tumor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThe enrollment of the first patient in this trial, especially during the ongoing COVID-19 pandemic, is a significant milestone for InteRNA,\u201d said Dr. Roel Schaapveld, CEO of InteRNA Technologies. \u201cmicroRNAs represent a new class of therapeutic agents that have the potential to change the treatment paradigm in immune-oncology, delivering a combination approach as a single regimen. We are very pleased that the first patient completed the first cycle without dose-limiting toxicity, and enrolment of the second cohort could already be initiated. The trial will allow us to generate further important insights on the potential and underlying mechanisms of INT-1B3 and reinforces our commitment to bringing this novel modality to patients, especially for the treatment of hard-to-treat solid tumors.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This two-part, open-label, multiple ascending dose Phase I\/Ib trial (<a href=\"http:\/\/r20.rs6.net\/tn.jsp?f=001M5Xu_IsFLzj2oN3mdz3V53tRNu5xk66YTYtVLgSSpHUtfhRPpR_1W_x8XYWs6WHVSXTFI6gpRWtyOsjQb5laFErT88AC2DKy24Qtdv7cMRj7-gqck0Jz7TYfqQOw5NeqCkx-IRl_98FBBHw6_tErXvEZNIdOl6ykY5BTr_CvIaEgy9ifFuwc2g==&amp;c=2Nmzju-GvmC-TZgVo6_dAx-QWd7pJ3EwwxajloM7DR53l-nZPsSlRQ==&amp;ch=xlHfkWxE4NHjp29M68pqxp6cDhp18rTOCS0XKYBAodtW9eti2_KTUQ==\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04675996<\/a>) will evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of INT-1B3. The dose escalation part of the study (part 1) will be conducted in trial sites located in the Netherlands and Belgium and will enroll approximately 30 patients with advanced solid tumors. The dose expansion part of the trial (part 2) will be conducted in multiple clinical study centers located in several European countries as well as in the United States and will enroll up to 50 patients with hepatocellular carcinoma or triple negative breast cancer. All patients will receive INT-1B3 via infusions twice per week in 21-day cycles. Topline results from the dose escalation part of the study are expected by the end of 2021.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Source: InteRNA Technologies (<a href=\"https:\/\/interna-technologies.com\/_WPIT\/wp-content\/uploads\/2021\/02\/210216_InteRNA_PR-First-Patient-Dosed_Final-1.pdf\">Press release<\/a>)<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>InteRNA Technologies announced today that the first patient has been dosed in the first cohort of its first-in-human Phase I study with the Company\u2019s lead microRNA candidate, INT-1B3. The trial will evaluate safety and initial signs of efficacy of INT-1B3, a microRNA-mimic of the endogenous tumor suppressor miR-193a-3p formulated in next-generation lipid nanoparticles, in patients [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-18995","post","type-post","status-publish","format-standard","hentry","category-gezondheid"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>InteRNA Technologies Announces Dosing of First Patient in First-in-Human Trial of microRNA Drug Candidate INT-1B3 in Patients with Advanced Solid Tumors - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"InteRNA Technologies Announces Dosing of First Patient in First-in-Human Trial of microRNA Drug Candidate INT-1B3 in Patients with Advanced Solid Tumors - hollandbio\" \/>\n<meta property=\"og:description\" content=\"InteRNA Technologies announced today that the first patient has been dosed in the first cohort of its first-in-human Phase I study with the Company\u2019s lead microRNA candidate, INT-1B3. The trial will evaluate safety and initial signs of efficacy of INT-1B3, a microRNA-mimic of the endogenous tumor suppressor miR-193a-3p formulated in next-generation lipid nanoparticles, in patients [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\/\" \/>\n<meta property=\"og:site_name\" content=\"hollandbio\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-16T13:37:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-16T13:37:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2025\/01\/hb-opengraph_illu.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"HollandBIO\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:site\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"HollandBIO\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\\\/\"},\"author\":{\"name\":\"HollandBIO\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/person\\\/48824449f08e494bb7ea02e1ff5dd6ea\"},\"headline\":\"InteRNA Technologies Announces Dosing of First Patient in First-in-Human Trial of microRNA Drug Candidate INT-1B3 in Patients with Advanced Solid Tumors\",\"datePublished\":\"2021-02-16T13:37:25+00:00\",\"dateModified\":\"2021-02-16T13:37:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\\\/\"},\"wordCount\":378,\"publisher\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\"},\"articleSection\":[\"Gezondheid\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\\\/\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/interna-technologies-announces-dosing-of-first-patient-in-first-in-human-trial-of-microrna-drug-candidate-int-1b3-in-patients-with-advanced-solid-tumors\\\/\",\"name\":\"InteRNA Technologies Announces Dosing of First Patient in First-in-Human Trial of microRNA Drug Candidate INT-1B3 in Patients with Advanced Solid Tumors - 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