{"id":15922,"date":"2019-10-30T18:28:47","date_gmt":"2019-10-30T17:28:47","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=15922"},"modified":"2019-11-05T18:32:56","modified_gmt":"2019-11-05T17:32:56","slug":"harvard-and-mit-experts-develop-new-gene-editing-technology","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/harvard-and-mit-experts-develop-new-gene-editing-technology\/","title":{"rendered":"Harvard and MIT Experts Develop New Gene Editing Technology"},"content":{"rendered":"\n

Experts from Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University developed a new\u00a0gene editing\u00a0approach by putting together two of the most vital proteins in molecular biology,\u00a0CRISPR-Cas9\u00a0and a reverse transcriptase, into one system. The new system called prime editing is capable of editing mammalian cells in a precise, efficient, and highly versatile fashion. The study was published in\u00a0Nature<\/em>.<\/p>\n\n\n\n

The main difference of prime editing from previous\u00a0genome editing\u00a0systems is that it uses RNA to direct the insertion of new DNA sequences in human cells. The new system involves combining Cas9 with reverse transcriptase. The molecular complex uses one strand of the target DNA site to “prime,” or initiate, the direct writing of edited genetic information into the genome. The system also uses a a new type of engineered guide RNA (pegRNA), which directs the prime editor to its target site where a modified Cas9 cuts one strand of the DNA.<\/p>\n\n\n\n

Read the articles in\u00a0Nature<\/strong><\/a> and\u00a0Science Daily<\/strong><\/a>\u00a0for more details.<\/p>\n\n\n\n

Source: ISAAA<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Experts from Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University developed a new\u00a0gene editing\u00a0approach by putting together two of the most vital proteins in molecular biology,\u00a0CRISPR-Cas9\u00a0and a reverse transcriptase, into one system. The new system called prime editing is capable of editing mammalian cells in a precise, efficient, and highly versatile fashion. […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46],"tags":[],"class_list":["post-15922","post","type-post","status-publish","format-standard","hentry","category-voedsel-materialen"],"acf":[],"yoast_head":"\nHarvard and MIT Experts Develop New Gene Editing Technology - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/harvard-and-mit-experts-develop-new-gene-editing-technology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Harvard and MIT Experts Develop New Gene Editing Technology - hollandbio\" \/>\n<meta property=\"og:description\" content=\"Experts from Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University developed a new\u00a0gene editing\u00a0approach by putting together two of the most vital proteins in molecular biology,\u00a0CRISPR-Cas9\u00a0and a reverse transcriptase, into one system. The new system called prime editing is capable of editing mammalian cells in a precise, efficient, and highly versatile fashion. 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