{"id":14155,"date":"2019-06-13T16:09:02","date_gmt":"2019-06-13T14:09:02","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=14155"},"modified":"2019-06-18T16:10:34","modified_gmt":"2019-06-18T14:10:34","slug":"study-results-show-improvement-multiple-myeloma-care","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/study-results-show-improvement-multiple-myeloma-care\/","title":{"rendered":"Study results show improvement multiple myeloma care"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">A substantial number of blood cancer (multiple myeloma) patients could make more informed decisions on their treatment if more information becomes available for them and their treating physicians. Interim results of a clinical study, executed by 6 renowned US hospitals [1], show that&nbsp;<strong>a physician can improve diagnosis in 42% of cases<\/strong>&nbsp;by using a reliable, robust and standardized test that assigns a risk profile [2]. Evidence is building up that patients live longer and in better health when you treat low-, standard- and high-risk patients differently [3-4]. Furthermore,&nbsp;<strong>79% of patients want to know their risk profile as this is directly linked to their prognosis<\/strong>&nbsp;[5]. The data demonstrates that the test would provide value to patients in standard clinical practice. For the diagnostic test to be adopted by international guidelines, it needs be reviewed by associations like ASCO, ESMO, IMWG and EMN.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI would really appreciate having the SKY92 test available outside the clinical study in order to tailor my treatment decisions and offer my patients a more personalized prognostic outlook\u201d, comments Parameswaran Hari, one of US\u2019 foremost authorities on multiple myeloma, practicing physician and principal investigator in the above mentioned ongoing clinical study.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SKY92 is able to assign one of three risk profiles at the moment of diagnosis. Published data show that high-risk patients who won\u2019t have a stem cell transplantation, appear to live longer when treated with lenalidomide (55 months) compared to thalidomide (17 months) [3]. Another study in favor of risk directed treatment was published last year. Standard of care for most patients is to undergo a stem cell transplantation. However, when a patient is low-risk, a non-transplant strategy gives them a better outlook (95% alive after 4 years versus 72%) and saves them a strenuous regimen. High-risk patients show improved outcomes on a transplant strategy (68% alive after 4 years versus 22%) [4].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI am blown away by the interim results of our clinical study\u201d, says Dharminder Chahal, CEO SkylineDx that developed the SKY92 test. \u201cWe now know that our test makes additional, crucial information available to patients and physicians in 42% of cases. We therefore must increase our efforts to make this test available to all multiple myeloma patients at an accelerated pace. In this pursuit I insist on collaboration with and from guideline committees, regulatory authorities and payors\u201d, concludes Dharminder Chahal.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Source: <a href=\"https:\/\/www.skylinedx.com\/news\"><strong>SkylineDx<\/strong><\/a><br>\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Footnotes<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Lombardi Comprehensive Cancer Center (Washington, Washington DC), Hackensack University Medical Center (Hackensack, New Jersey), Columbia University Medical Center (New York, New York), Weill Cornell Medicine (New York, New York), Levine Cancer Institute (Charlotte, North Carolina) and Medical College of Wisconsin (Milwaukee, Wisconsin).<\/li><li>Hari, et al. 2019. EHA Abstract PF620 (<a href=\"https:\/\/library.ehaweb.org\/eha\/2019\/24th\/266419\/parameswaran.hari.comparison.of.riss.and.imwg.risk.stratification.guidelines.html?f=menu%3D6%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D3%2Ace_id%3D1550%2Aot_id%3D20963\">link<\/a>). Poster presentation at EHA on Friday, June 14, 2019 from 5.30-7PM, poster area. Amsterdam RAI Exhibition and Convention Centre, Amsterdam, The Netherlands.<\/li><li>Kuiper, et al. 2019. EHA Abstract PS1374 (<a href=\"https:\/\/library.ehaweb.org\/eha\/2019\/24th\/266991\/rowan.kuiper.prognosis.in.elderly.multiple.myeloma.patients.in.the.hovon-87.html?f=menu%3D6%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D3%2Ace_id%3D1550%2Aot_id%3D20963\">link<\/a>). Poster presentation at EHA on Saturday, June 15, 2019 from 5.30-7PM, poster area. Amsterdam RAI Exhibition and Convention Centre, Amsterdam, The Netherlands.<\/li><li>Hofste op Bruinink, et al. 2018. ASH Abstract 3186.<\/li><li>To be published later in addition to Van Dongen \u2013 Leunis, et al. 2019. EHA Abstract PF727 (<a href=\"https:\/\/library.ehaweb.org\/eha\/2019\/24th\/266526\/annemieke.van.dongen.-.leunis.does.quality.of.life.in.multiple.myeloma.html?f=listing%3D4%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D3%2Aspeaker%3D729777\">link<\/a>). Poster presentation at EHA on Friday, June 14, 2019 from 5.30-7PM, poster area. Amsterdam RAI Exhibition and Convention Centre, Amsterdam, The Netherlands.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>A substantial number of blood cancer (multiple myeloma) patients could make more informed decisions on their treatment if more information becomes available for them and their treating physicians. Interim results of a clinical study, executed by 6 renowned US hospitals [1], show that&nbsp;a physician can improve diagnosis in 42% of cases&nbsp;by using a reliable, robust [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-14155","post","type-post","status-publish","format-standard","hentry","category-gezondheid"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Study results show improvement multiple myeloma care - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/study-results-show-improvement-multiple-myeloma-care\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study results show improvement multiple myeloma care - hollandbio\" \/>\n<meta property=\"og:description\" content=\"A substantial number of blood cancer (multiple myeloma) patients could make more informed decisions on their treatment if more information becomes available for them and their treating physicians. 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