{"id":11704,"date":"2018-12-13T17:15:39","date_gmt":"2018-12-13T16:15:39","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=11704"},"modified":"2018-12-18T21:43:34","modified_gmt":"2018-12-18T20:43:34","slug":"mymetics-virosomes-successful-in-allergy-proof-of-concept-study","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/mymetics-virosomes-successful-in-allergy-proof-of-concept-study\/","title":{"rendered":"Mymetics Virosomes Successful in Allergy Proof-of-Concept Study"},"content":{"rendered":"<p>Mymetics, a pioneer and leader in the research and development of virosome-based vaccines against life threatening and life disabling diseases, announced that the pre-clinical proof-of-concept study for allergies, with their partner Anergis, has met the success criteria.<\/p>\n<p>&nbsp;<\/p>\n<p>The mice proof-of-concept immunogenicity study evaluated the effects of the Bet v 1 COPs (Anergis\u2019 proprietary birch pollen allergy peptides) using the five subcutaneous injection schedule used in former AllerT clinical trials. The development of AllerT (Bet v 1 COPs plus aluminum hydroxide) was discontinued by Anergis in 2017 following completion of a Phase 2 clinical trial showing evidence of sensitization to the peptides and a 7% reduction in seasonal allergy symptoms vs placebo (p=0.0047).<\/p>\n<p>&nbsp;<\/p>\n<p>In the mice study, AllerT was compared to Bet v 1 COPs linked to Mymetics\u2019 virosomes (the \u201cBet v 1 COP-virosomes\u201d). Anergis reported that the administration of AllerT led to the development of Bet v 1 specific IgEs (p&lt;0.001) associated with a more pronounced TH2 than TH1 response. In contrast, in the mice receiving the Bet v 1 COP-virosomes, no development of Bet v 1 specific IgEs were observed (p&lt;0.001 vs AllerT). With the same dose of Bet v 1 COPs, there was a strong boost of immunogenicity with a TH1 antibody response, which was a hundred times greater than with aluminum hydroxide (p&lt;0.001). The Bet v 1 COP-virosomes were well tolerated.<\/p>\n<p>&nbsp;<\/p>\n<p>This study is part of the research collaboration agreement between Anergis and Mymetics which was signed in April 2018. The success criteria were met and Anergis has now a time limited option to enter into an exclusive license agreement with Mymetics for the use of virosomes in the field of allergies.<\/p>\n<p>&nbsp;<\/p>\n<p>Ronald Kempers, CEO of Mymetics, stated: \u201cThe results from Anergis are very encouraging and show that our virosomes can have a broad application in vaccines, not only for prevention of infectious diseases but also in the field of immunotherapy for allergies.\u201d<\/p>\n<p>Source: <span style=\"text-decoration: underline;\"><strong><a href=\"https:\/\/www.mymetics.com\/media-center\/mymetics-virosomes-successful-allergy-proof-concept-study\/\">Mymetics<\/a><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mymetics, a pioneer and leader in the research and development of virosome-based vaccines against life threatening and life disabling diseases, announced that the pre-clinical proof-of-concept study for allergies, with their partner Anergis, has met the success criteria. &nbsp; The mice proof-of-concept immunogenicity study evaluated the effects of the Bet v 1 COPs (Anergis\u2019 proprietary birch [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-11704","post","type-post","status-publish","format-standard","hentry","category-gezondheid"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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