{"id":10872,"date":"2018-09-13T22:41:04","date_gmt":"2018-09-13T20:41:04","guid":{"rendered":"https:\/\/www.hollandbio.nl\/?p=10872"},"modified":"2018-09-18T22:47:08","modified_gmt":"2018-09-18T20:47:08","slug":"temple-therapeutics-published-key-mechanism-data-for-evitar","status":"publish","type":"post","link":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/","title":{"rendered":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122"},"content":{"rendered":"<p>Temple Therapeutics, a clinical stage biopharmaceutical company focused in developing therapeutics for fibrosis and oncology, announces the publication of groundbreaking mechanistic data for Evitar\u2122 in Reproductive Sciences, a peer reviewed journal of the Society of Reproductive Investigations.\u00a0 The publication includes data to support a credible hypothesis for Evitar\u2122\u2019s mechanism of action advanced by Temple\u2019s CSO, Dr. Lynne Robertson.\u00a0 This hypothesis proposes that novel drug candidate Evitar\u2122\u00a0 modulates key upstream inflammatory mediators, such Hypoxia Inducible Factor 1 Alpha (HIF1-\u03b1) and Type 1 Collagen, which, when left unchecked, promote abnormal healing and tissue fibrosis.<\/p>\n<p>Additionally, data from the Evitar\u2122 proof-of-concept randomized clinical trial was recently accepted for presentation at 47th Annual Global Congress of AAGL (American Association of Gynecologic Laparoscopists) scheduled for November 2018.<\/p>\n<p>\u201cPost-surgical adhesions are broadly recognized as the single greatest cause of surgical complications. Moreover, they have evaded effective intervention, until now\u201d comments Sanj Singh, CEO of Temple.\u00a0 \u201cThese mechanism-of-action and randomized clinical trial data speak to the underlying biology driving surgical adhesions.\u00a0 We are pleased to note the publication\u2019s acceptance in Reproductive Sciences, a high-impact, peer-reviewed journal.\u00a0 This publication and the forthcoming AAGL presentation further support the Evitar\u2122 value proposition.\u00a0 Adhesion prevention is only the beginning.\u00a0 However, it provides a relevant model to further the study of both fibrosis and cancer pathophysiology.\u00a0 Temple is leveraging these insights to further its pipeline of first-in-class therapeutics for the management of adhesions, endometriosis and ovarian cancer.\u201d<\/p>\n<p><span style=\"text-decoration: underline;\"><strong><a href=\"http:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/1933719118789511\"> Robertson, L., King, N., Diamond, M., &amp; Saed, G., Evitar\u2122(l-Alanyl-l-Glutamine) Regulates Key Signaling Molecules in the Pathogenesis of Postoperative Tissue Fibrosis, Reproductive Sciences, September 5, 2018<\/a> <\/strong><\/span><\/p>\n<p>Source:<span style=\"text-decoration: underline;\"><strong><a href=\"file:\/\/\/C:\/Users\/Leonie%20White\/AppData\/Local\/Microsoft\/Windows\/INetCache\/Content.Outlook\/QZHPT317\/Press%20Release_Sept13_2018.pdf\"> Temple Therapeutics<\/a><\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Temple Therapeutics, a clinical stage biopharmaceutical company focused in developing therapeutics for fibrosis and oncology, announces the publication of groundbreaking mechanistic data for Evitar\u2122 in Reproductive Sciences, a peer reviewed journal of the Society of Reproductive Investigations.\u00a0 The publication includes data to support a credible hypothesis for Evitar\u2122\u2019s mechanism of action advanced by Temple\u2019s CSO, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-10872","post","type-post","status-publish","format-standard","hentry","category-gezondheid"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio\" \/>\n<meta property=\"og:description\" content=\"Temple Therapeutics, a clinical stage biopharmaceutical company focused in developing therapeutics for fibrosis and oncology, announces the publication of groundbreaking mechanistic data for Evitar\u2122 in Reproductive Sciences, a peer reviewed journal of the Society of Reproductive Investigations.\u00a0 The publication includes data to support a credible hypothesis for Evitar\u2122\u2019s mechanism of action advanced by Temple\u2019s CSO, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/\" \/>\n<meta property=\"og:site_name\" content=\"hollandbio\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-13T20:41:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-09-18T20:47:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2025\/01\/hb-opengraph_illu.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"hollandbio\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:site\" content=\"@hollandbio\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hollandbio\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/\"},\"author\":{\"name\":\"hollandbio\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/person\\\/833d6a25b39946e61c6101af1fa96fbb\"},\"headline\":\"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122\",\"datePublished\":\"2018-09-13T20:41:04+00:00\",\"dateModified\":\"2018-09-18T20:47:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/\"},\"wordCount\":272,\"publisher\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\"},\"articleSection\":[\"Gezondheid\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/\",\"name\":\"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#website\"},\"datePublished\":\"2018-09-13T20:41:04+00:00\",\"dateModified\":\"2018-09-18T20:47:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/nieuws\\\/temple-therapeutics-published-key-mechanism-data-for-evitar\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\",\"name\":\"hollandbio\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#organization\",\"name\":\"hollandbio\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.hollandbio.nl\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/HollandBIO_logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.hollandbio.nl\\\/wp-content\\\/uploads\\\/2023\\\/08\\\/HollandBIO_logo.svg\",\"width\":218.664,\"height\":29.659,\"caption\":\"hollandbio\"},\"image\":{\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/hollandbio\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/hollandbio\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.hollandbio.nl\\\/en\\\/#\\\/schema\\\/person\\\/833d6a25b39946e61c6101af1fa96fbb\",\"name\":\"hollandbio\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/","og_locale":"en_US","og_type":"article","og_title":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio","og_description":"Temple Therapeutics, a clinical stage biopharmaceutical company focused in developing therapeutics for fibrosis and oncology, announces the publication of groundbreaking mechanistic data for Evitar\u2122 in Reproductive Sciences, a peer reviewed journal of the Society of Reproductive Investigations.\u00a0 The publication includes data to support a credible hypothesis for Evitar\u2122\u2019s mechanism of action advanced by Temple\u2019s CSO, [&hellip;]","og_url":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/","og_site_name":"hollandbio","article_published_time":"2018-09-13T20:41:04+00:00","article_modified_time":"2018-09-18T20:47:08+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2025\/01\/hb-opengraph_illu.png","type":"image\/png"}],"author":"hollandbio","twitter_card":"summary_large_image","twitter_creator":"@hollandbio","twitter_site":"@hollandbio","twitter_misc":{"Written by":"hollandbio","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/#article","isPartOf":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/"},"author":{"name":"hollandbio","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/person\/833d6a25b39946e61c6101af1fa96fbb"},"headline":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122","datePublished":"2018-09-13T20:41:04+00:00","dateModified":"2018-09-18T20:47:08+00:00","mainEntityOfPage":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/"},"wordCount":272,"publisher":{"@id":"https:\/\/www.hollandbio.nl\/en\/#organization"},"articleSection":["Gezondheid"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/","url":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/","name":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122 - hollandbio","isPartOf":{"@id":"https:\/\/www.hollandbio.nl\/en\/#website"},"datePublished":"2018-09-13T20:41:04+00:00","dateModified":"2018-09-18T20:47:08+00:00","breadcrumb":{"@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.hollandbio.nl\/en\/nieuws\/temple-therapeutics-published-key-mechanism-data-for-evitar\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.hollandbio.nl\/en\/"},{"@type":"ListItem","position":2,"name":"Temple Therapeutics Published Key Mechanism Data for Evitar\u2122"}]},{"@type":"WebSite","@id":"https:\/\/www.hollandbio.nl\/en\/#website","url":"https:\/\/www.hollandbio.nl\/en\/","name":"hollandbio","description":"","publisher":{"@id":"https:\/\/www.hollandbio.nl\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.hollandbio.nl\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.hollandbio.nl\/en\/#organization","name":"hollandbio","url":"https:\/\/www.hollandbio.nl\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2023\/08\/HollandBIO_logo.svg","contentUrl":"https:\/\/www.hollandbio.nl\/wp-content\/uploads\/2023\/08\/HollandBIO_logo.svg","width":218.664,"height":29.659,"caption":"hollandbio"},"image":{"@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/hollandbio","https:\/\/www.linkedin.com\/company\/hollandbio\/"]},{"@type":"Person","@id":"https:\/\/www.hollandbio.nl\/en\/#\/schema\/person\/833d6a25b39946e61c6101af1fa96fbb","name":"hollandbio"}]}},"_links":{"self":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts\/10872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/comments?post=10872"}],"version-history":[{"count":0,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/posts\/10872\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/media?parent=10872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/categories?post=10872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hollandbio.nl\/en\/wp-json\/wp\/v2\/tags?post=10872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}