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Avantium begint bouw demonstratiefabriek

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Chemisch technologiebedrijf Avantium is begonnen met de bouw van een nieuwe demonstratiefabriek in Nederland voor de productie van biologische ethyleenglycol uit hernieuwbare suikers. De faciliteit moet in 2019 in gebruik worden en krijgt maximaal twintig werknemers.

Volgens Avantium maakt de nieuwe fabriek deel uit van een eerder aangekondigde investering van 15 miljoen tot 20 miljoen euro in nieuwe technologieën. Ethyleenglycol is een belangrijk bestanddeel voor plastic producten. Avantium stelt dat op biologische basis geproduceerde ethyleenglycol een sterk groeipotentieel heeft.

Verder gaf Avantium aan dat zijn bioraffinaderij in Delfzijl bijna klaar is. In die fabriek worden houtsnippers met behulp van zoutzuur omgezet in glucose en lignine.

Bron: IEX

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Vertoro receives Seed Financing from Chemelot Ventures and LIOF

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Chemelot Ventures, LIOF and the founders will invest €500,000 in Vertoro, a company located on the Brightlands Chemelot Campus in Geleen. Vertoro has developed a biobased process to derive bio-oil from waste product lignin (biomass) and will use the funds to scale up production. As bio-oil is made from biomass, it helps to reduce CO2 emissions and paves the way for the production of sustainable products.

Vertoro: developer and producer of bio-oil
Vertoro, which is located on the Brightlands Chemelot Campus in Geleen, is the outcome of a project by Chemelot InSciTe, a public-private partnership. An initial upscaling of the bio-oil has already been completed as part of this project. Vertoro and InSciTe are now preparing to construct a pilot plant on the Brightlands Chemelot Campus in Geleen. In early 2019, Vertoro expects to be the first company in the world to produce a barrel of bio-oil from lignin. The company then aims to build a production facility at Chemelot in 2022 with an annual production capacity of 10,000 tonnes of bio-oil.

Vertoro, founded in 2017, was a participant in the Brightlands Innovation Factory’s start-up programme in the same year. This is part of the reason that the company is now ready for the current Seed Financing by Chemelot Ventures and LIOF.

Vertoro derives bio-oil from the raw material lignin is a wood polymer found in the cell wall of plants and trees. Currently, lignin is  a by-product in the production of paper and biofuels (bioethanol) and burnt as a waste stream. Vertoro and its development partners have succeeded in developing a technology to convert lignin into valuable bio-oil through an innovative production process that can make an important contribution towards reducing CO2 emissions.

Increasing demand for bio-oil
Global demand for bio-oil is increasing, particularly from industrial companies looking to produce sustainable products from biomass. Similar to fossil-based oil, Vertoro’s bio-oil can be used as a basic raw material for applications in energy (i.e. additive for biodiesel), chemicals, and materials (i.e. bio-phenol for plastics).

Suppliers of lignin also have a keen interest in Vertoro’s production process, as this is the first time that there has been an efficient process for converting the low-grade lignin into a raw material for high-grade products. Following the local upscaling, Vertoro – literally ‘green gold’ – will license out the technology and market bio-oil worldwide.

Michael Boot CEO of Vertoro and Panos Kouris CTO of Vertoro: ‘Our bio-oil provides a fantastic basis for producing clean energy and sustainable chemicals and materials. We can see that Brightlands brings together all these success factors.’

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‘Sexy plants’ on track to replace harmful pesticides to protect crops

Researchers are genetically engineering plants to produce the sex pheromones of insects, which then frustrate the pests’ attempts to mate.

“Sexy plants” are on the way to replacing many harmful pesticides, scientists say, by producing the sex pheromones of insects which then frustrate pests’ attempts to mate.

Scientists have already genetically engineered a plant to produce the sex pheromones of moths and are now optimising that, as well as working on new pheromones such as those of the mealybugs that plague citrus growers.

Sex pheromones are already used to protect some higher-value crops, such as tomatoes and berries. But the complex molecules are currently produced by chemical synthesis, which is expensive.

The new work uses a plant as a bio-factory, powered by the sun. Other researchers are also working on brewing sex pheromones using genetically modified yeast, a process already widely used to make, for example, insulin for diabetic patients.

Existing pesticides often harm both pests and beneficial insects, such as bees. Some are now pervasive in the environment around the world and are partly to blame for crashing insect populations. The world’s most widely used insecticides, neonicotinoids, were banned from outdoor use by the European Union in April. In contrast, pheromones are specific to each species and, being used in tiny amounts in fields, do not contaminate the wider area.

“For many species, pheromone manufacturing is difficult and expensive,” said Nicola Patron, at the Earlham Institute, UK, which has received three years of European funding for the new project, along with scientists in Spain, Germany and Slovenia. “Bioengineering can provide viable alternatives to manufacturing, expanding the use of pheromones that will be much kinder to our environment.”

A pilot project called SexyPlant created a genetically modified tobacco plant that produces and releases the sex pheromones of the cotton bollworm and navel orangeworm, both larvae of moths. This is now being improved to give bigger yields. The same plant has already been engineered by others to produce ebola antibodies and polio vaccine.

In the new work, the pheromone will first be harvested from the plant and put in traps or dispensers to prevent pests mating. But in future, plants producing the pheromones could be planted alongside the crops they protect. This will prevent females finding mates and laying their eggs on crops, which the larvae then destroy, but will not affect the insects away from the field.

Patron and her colleagues are also isolating pheromones from citrus mealybugs, chosen because they are particularly complex molecules. “If we can do these, we can probably do most things,” said Patron.

She said crop plants were not themselves being engineered to produce pheromones, so no GM material would be in the final produce. Pheromones harvested from the plants could be used in fields quite soon, but putting pheromone-producing plants in fields is 10-15 years away, Patron said, because of the long regulatory process for GM plants.

Other scientists, at the Technical University of Denmark (DTU), are exploring using engineered yeast cells to produce pheromones. “We aim to produce pheromones by fermentation and it will make the pheromones affordable for the protection of row crops, like maize and soybean,” said Irina Borodina at DTU.

One of the pests her group is targeting is the fall armyworm, which poses a major threat to food security in Africa and elsewhere. “African farmers have tried to treat this pest with insecticides, but it has become resistant,” said Borodina. “So there is an urgent need for a solution because otherwise people will starve.”

Different approaches are welcomed by Patron, whose group is also exploring the potential of fungi to produce pheromones: “At this stage of biomanufacturing, there is not one perfect solution and it definitely makes sense we try it across different types of organisms and see what is going to work.”

Chris Hartfield, at the National Farmers’ Union in England, said: “Looking for alternative ways of effectively controlling the many crop pests farmers face is at the heart of the integrated pest management approach taken by farmers and growers. Using pheromones and other biopesticides, where available, is an important part of that approach.

“Farmers are in the job of producing safe, traceable and affordable food, so the critical thing for them is to have an effective crop protection toolbox available to combat pests today,” he said. “If they lose a pesticide from that toolbox, food production could be severely impacted if the effective alternative is several years away at the end of a research project.”

Source: The Guardian

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Organic insect deterrent for agriculture

Traditional insecticides are killers: they not only kill pests, they also endanger bees and other beneficial insects, as well as affecting biodiversity in soils, lakes, rivers and seas. A team from the Technical University of Munich (TUM) has now developed an alternative: A biodegradable agent that keeps pests at bay without poisoning them.

“It’s not just about the bees, it’s about the survival of humanity,” says Professor Thomas Brück, who heads the Werner Siemens Chair of Synthetic Biotechnology at TU Munich. “Without the bees that pollinate a wide variety of plants, not only would our supermarket shelves be quite bare, but within a short time, it would no longer be possible to supply the world’s population with food.”

Synthetically produced insecticides endanger not only bees but also beetles, butterflies and grasshoppers. They affect biodiversity in soils, lakes, rivers and seas. Their use has consequently been highly controversial for many years.

Repelling instead of poisoning

Brück and his team have now found an alternative: The insect repellent they have developed is biodegradable and ecologically harmless. Sprayed on plants, it works much like mosquito repellent used by bathers in the summer, spreading a smell that keeps away unwanted insects.

“With our approach, we are opening the door to a fundamental change in crop protection,” says Brück. “Instead of spraying poison, which inevitably also endangers useful species, we deliberately merely aggravate the pests.”

 

Bacteria as chemical factories

The Munich researchers were inspired by the tobacco plant, which produces cembratrienol in its leaves, CBTol for short. The plant uses this molecule to protect itself from pests.

Using synthetic biotechnology tools, Professor Brück’s team isolated the sections of the tobacco plant genome responsible for the formation of the CBTol molecules. They then built these into the genome of coli bacteria. Fed with wheat bran, a by-product from grain mills, the genetically modified bacteria now produce the desired active agent.

 

Efficiency in small and large scales

“The key challenge during production was to separate the active ingredients from the nutrient solution at the end of the process,” explains Mirjana Minceva, Professor of Biothermodynamics at the TUM Weihenstephan Campus.

The solution was centrifugal separation chromatography: a highly efficient process that works equally well on an industrial scale, but hitherto, had never been used to separate products from fermentation processes.

 

Equally effective against bacteria

Initial investigations indicate that the CBTol spray is non-toxic to insects, yet still protects against aphids. Since it is biodegradable, it does not accumulate.

In addition, the bioactivity tests showed that cembratrienol has an antibacterial effect on gram-positive bacteria. It can thus be used as a disinfectant spray that acts specifically against pathogens such as Staphylococcus aureus (MRSA pathogen), Streptococcus pneumoniae (pneumonia pathogen) or Listeria monocytogenes (listeriosis pathogen).

 

Publication

Wolfgang Mischko, Max Hirte, Simon Roehrer, Hannes Engelhardt, Norbert Mehlmer, Mirjana Minceva and Thomas BrückModular Biomanufacturing for a Sustainable Production of Terpenoid-based Insect DeterrentsGreen chemistry, May 14, 2018

Source: Technical University of Munich

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Ambachtelijke bierbrouwers veredelen modern

De Nederlandse hop sterft uit. Dit tot groot verdriet van de lokale bierbrouwers. Daarom zijn twee ambachtelijke brouwers samen met Hogeschool Inholland en Wageningen University, een project gestart om de sterke eigenschappen en authentieke smaak van de oude hop rassen weer in de huidige rassen te zetten. De onderzoekers ontleden eerst de genetische en chemisch samenstelling van de oude rassen. Deze kennis gebruiken ze vervolgens om weer authentieke Nederlandse hop variëteiten te maken. Haast is geboden, dus zullen de modernste veredelingsmethoden hierbij worden ingezet. HollandBIO juicht deze ambachtelijke en moderne kruisbestuiving toe en kan niet wachten om het eerste biertje te proeven!

Lees het hele originele artikel hier (alleen voor abonnees van het Parool).

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GM golden rice gets approval from food regulators in the US

GOLDEN rice, which has been genetically modified to prevent blindness in undernourished children, was judged safe to eat last week by the US Food and Drug Administration.

The rice contains extra genes that make a precursor to vitamin A, which is vital for preventing childhood blindness. A single helping can supply half the recommended daily intake of vitamin A, according to its developers at the International Rice Research Institute in the Philippines. The genes also give it its distinctive golden hue.

The nod by the FDA makes the US the fourth country to approve the rice this year, behind Canada, Australia and New Zealand. Having the rice cleared in these countries means there would be no regulatory issues if they imported food containing small quantities of the rice.

But its developer says the most important approvals are still awaited in the Philippines and Bangladesh, where the rice could have the greatest impact. Applications were lodged there last year.

Source: New Scientist

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Pink pineapples and healthy fries

From health benefits to increased flavour and longer shelf-life, discover the new generation of GM foods designed with the consumer in mind.

Non-browning apples

Some people dislike eating fruit with flesh that has become discoloured. This never happens to Arctic apples. They went on sale in the US in November 2017.

Potatoes that don’t bruise

The Innate potato is less prone to bruising and consequent black spots. When fried, it also produces less acrylamide, a substance suspected of causing cancer, than conventional spuds do.

Wheat with “good” gluten

People with coeliac disease could soon have their cake and eat it. At least two groups worldwide are editing out the genes for the gluten proteins that damage the guts of people with this digestive disorder. One GM wheat is undergoing clinical trials in Spain.

Pink pineapples

They are pink because they accumulate lycopene, the pigment that makes tomatoes red, instead of converting it into yellow beta-carotene as normal pineapples do. The US gave the green light for this variety to be eaten in December 2016, but it is yet to go on sale. Lycopene is thought to have various health benefits. The pink pineapples are also said to be sweeter – and add a twist to a pina colada.

Omega-3 rapeseed (canola)

This seed from the rape plant is rich in the beneficial omega-3 oil DHA. The plan is to market it first as fish feed and then for human consumption. Last year, 1200 hectares were grown and harvested in the US.

High-fibre white bread

Gene-edited wheat yields white flour with three times as much dietary fibre as standard white flour.

Bloodier oranges

Blood oranges are regarded as beneficial because they are rich in antioxidants called anthocyanins. Normal blood oranges only turn red if they experience cold nights while growing. The GM strain is full of anthocyanins regardless of the weather. The oranges are not yet on sale.

Bananas with a boost

The matoke cooking banana is a staple in Uganda. The GM variety contains provitamin A, a lack of which can lead to blindness. It is being field tested in Uganda and could be on sale in 2021.

Lower-saturated fat rapeseed oil

Conventional rapeseed oil contains 7 per cent saturated fats. A gene-edited variety will have half this amount.

Golden rice

Rice designed to reduce vitamin A deficiency has been under development for decades, but has yet to reach market. It received a big boost earlier this year when Australia, New Zealand and Canada declared it safe for humans, meaning there would be no regulatory issues if those countries imported food containing small quantities of the rice.

Source: New Scientist

 

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Shriram and KeyGene Join Forces To Develop Improved Hybrid Rice

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Shriram Bioseed and KeyGene announce a multi-year strategic co-development research program for development of improved rice hybrids with higher yields, increased tolerance to abiotic stresses, and better grain quality for consumers in India and south east Asia. KeyGene’s innovation platforms will be exploited to boost these important traits in Bioseed’s elite rice germplasm. The program will lead to growth of hybrid rice markets in the region.

Under this partnership both companies will make joint investments. “The aim of this strategic investment is to generate value in rice by incorporating new traits that help vigorous growth of rice with customized preferences for consumers in different parts of India and in the South-East Asian rice market. The end goal is to benefit the rice farmers by providing them with seed of high performing hybrids”, says Arjen van Tunen, CEO of KeyGene.

“We are excited about our extended collaboration with KeyGene and the opportunity of using KeyGene’s proprietary technologies and innovation platforms to develop novel tools specifically for rice which will enable us to improve our products with increased precision and efficiency”, says Dr. Paresh Verma, Director Research at Shriram Bioseed.

Bron: Keygene

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FrieslandCampina launches “innovative plant material” cardboard liter pack

FrieslandCampina’s long-keeping chocolate milk brand, Chocomel, is set to be packaged in a new, innovative cardboard liter pack made up of 80 percent raw plant material from Tetra Pak. The move places Chocomel as the first product to be packed in the liter pack, of which wood and sugar are the parent materials.

The cartons’ 80 percent plant material make-up consists of cardboard made from wood that is 100 percent sourced from FSC-certified forests. The plastic cap and the outer plastic layer of the iconic yellow-colored pack are made from plants. The materials are based on waste plant material that is leftover once all the edible parts have been taken out, further enhancing the packaging as sustainable with a nod towards the circular economy.

Bron: Food ingredients 1st

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Kweekvlees is er! Maar we mogen niet proeven.

Door Koert van Mensvoort

Nederland is goed in kaas, klompen en kweekvlees. Deze duurzame en diervriendelijke vorm van vlees is grotendeels in ons land ontwikkeld. In 1997 verkreeg Willem van Eelen het eerste patent op de techniek, waarbij dierlijke cellen tot spierweefsel worden opgekweekt zonder dat er een dier voor hoeft te worden geslacht. De Nederlandse overheid investeerde begin deze eeuw flink in wetenschappelijk onderzoek dat werd uitgevoerd aan de universiteiten van Utrecht, Amsterdam en Eindhoven.

In 2013 werd door professor Mark Post van de Universiteit van Maastricht de eerste kweekburger aan de wereld gepresenteerd. Zelf deed ik vanaf 2011 aan de TU Eindhoven onderzoek naar de mogelijke impact en we publiceerden met Next Nature Network in 2014 het eerste Kweekvlees Kookboek, met als doel de maatschappelijke discussie over de toekomst van vlees te entameren.

Overmatige vleesconsumptie vormt volgens de Verenigde Naties een van de grootste milieuproblemen van onze tijd. Hoewel het algemeen bekend is dat de opwarming van de Aarde een probleem is, weten veel minder mensen dat vleesproductie een significant deel van de schadelijke broeikasgassen veroorzaakt. Wil Nederland de klimaatdoelen van Parijs halen, dan zal de veestapel hoe dan ook moeten krimpen in de komende jaren, aldus een recent rapport van de Raad voor de leefomgeving en infrastructuur. Omdat niet iedereen direct bereid is vegetariër te worden, en bovendien de vleesconsumptie in opkomende economieën zoals India en China tezamen met de welvaart toeneemt, moeten we alle alternatieven verkennen.

Hoewel veel mensen kweekvlees nu nog als kunstmatig en onnatuurlijk ervaren, is het maakproces vergelijkbaar met bierbrouwen of kaasmaken; beide draaien om het voeden van celculturen. Het belangrijke verschil is dat kweekvlees nieuw en daarmee ook vreemd en onwennig is. Misschien dat het aan het in 2050 heel gewoon is om in je eigen keuken een stukje vlees te kweken. Voorlopig is het ‘Wat de boer niet kent, de boer niet eet?’ Niet helemaal. Uit onderzoek naar de bereidheid om kweekvlees te consumeren blijkt dat tussen de 40 en 70% van de bevolking er voor open staat om kweekvlees te proberen of er zelfs volledig op over te schakelen.

Omdat de eerste kweekburger in 2013 nog 250.000 euro koste, lijkt deze meer duurzame en diervriendelijke vorm van vleesproductie misschien nog een ver van je bed show. Maar vergis je niet. De eerste platte televisies waren ook alleen betaalbaar voor miljonairs. Vandaag heeft vrijwel iedereen er een in de slaapkamer hangen.

Vlees is wereldwijd een miljarden industrie. Het bedrijf dat er in slaagt een deel van deze markt met kweekvlees te bedienen, draagt niet alleen bij aan een duurzamere wereld; er is potentieel ook veel geld mee te verdienen. Internationale investeerders is dit niet ontgaan. Wereldwijd zijn er op dit moment verschillende bedrijven actief om kweekvlees naar de markt te brengen.

Een van die bedrijven is het Amerikaanse JUST, dat zegt van eendencellen gekweekte nuggets, chorizo worst en zelfs kweek Foie Gras te hebben gemaakt. De CEO van dit bedrijf, Josh Tetrick, heeft de ambitie hun product nog in 2018 op de markt te brengen.

Omdat hij de Nederlandse historie in kweekvlees waardeert, leverde hij onlangs een eerste proefpartij kweekvlees aan een Nederlands restaurant, alsmede aan het NEMO Science Museum, met het idee zijn product op de plek van oorsprong aan de Wereld te presenteren.

Als kweekvlees verkenner van het eerste uur was ik uitgenodigd voor het diner en verheugd de producten te mogen proeven. Maar zover kwam het niet. Op aangeven van het Ministerie van VWS kwam een inspecteur van het Nederlandse Voedsel en Waren Autoriteit de pakketten kweekvlees verzegelen. Omdat dit product nog niet is goedgekeurd volgens Europese Novel food wetgeving mag het niet door ons worden geconsumeerd. In reactie hierop zal de presentatie waarschijnlijk in Azië plaatsvinden.

Nu breekt mijn klomp. We hebben als Nederland vanaf dag één een leidende rol gespeeld in deze duurzame innovatie. De overheid heeft geld geïnvesteerd in onderzoek. Nu een aantal belangrijke technische en maatschappelijke hordes rondom het maakproces en consumenten acceptatie genomen zijn, gaat diezelfde overheid een juridische horde opwerpen door de presentatie van het product in Nederland verbieden.

Begrijp me niet verkeerd. Ik begrijp dat de kweekvlees producten grondig moeten worden onderzocht en getest voordat we deze in de supermarkt aan de consument aanbieden. Is kweekvlees veilig? Is het gezond? We willen het allemaal weten. Daar mag geen twijfel over bestaan voordat het in de winkel komt. Maar daar kom je niet achter als je als overheidsinstantie een proefpakket kweekvlees verzegelt, waardoor je het niet eens meer kunt testen.

Nederland is wereldwijd bekend om onze kaas en ons heerlijk heldere bier. We hebben een unieke kans hier een nieuwe productcategorie aan toe te voegen. We hebben een topsectorenbeleid met de ambitie de meest creatieve economie van Europa te worden. We willen wereldwijd uitblinken op innovatie en voedselproductiviteit. En dan doen we dit?

Ik wil kamer vragen. Ik wil dat de minister de NVWA opdraagt de verzegeling per direct op te heffen en een actieve houding in te nemen door de nieuwe voedselwaren versneld te testen. Ik stel mijzelf beschikbaar om dit kweekvlees op eigen risico te proeven. En we zijn een petitie gestart. Teken als u ook kweekvlees wilt proeven.

Meer weten? Op zondag 27 mei om 21.05 is op NPO2 de VPRO Tegenlicht uitzending Vleeskwekers te zien

Bron: Next Nature Network