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In gesprek met plant-based: andere start, zelfde missie

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Begin deze maand mocht hollandbio’s Dora op uitnodiging van het Plant Based Netwerk West-Brabant een inkijkje geven in de dynamiek en kansen van het Nederlandse biotech-ecosysteem. En eerlijk is eerlijk, wat is het fijn om een middag door te brengen met ondernemers die net als in de biotech bezig zijn met de vraag: hoe krijgen we het voor elkaar? Want een goed idee is mooi, maar een uitstekende uitvoering is beter. En laat dat nou precies zijn waar ondernemers in uitblinken. Beginnen, proberen, aanpassen en vooral: blijven gaan.

Hoewel hollandbio normaal gesproken bij de biotech-leest blijft, voelde de verbinding met het plant-based netwerk heel logisch. We werken meestal vanuit verschillende technologieën, maar aan dezelfde transitie: slimmer, duurzamer en anders produceren, met alternatieven voor de grondstoffen en productiemethoden van vandaag.

Juist daarin versterken onze netwerken elkaar. Neem DKG De Keukenfabriek, die inzet op biobased keukens. Misschien zit daar vandaag nog weinig biotech in, maar zo’n ondernemer helpt wél de weg vrij te maken voor verandering: anders omgaan met grondstoffen, investeren in nieuwe productiemethoden en klanten laten ervaren dat een alternatief ook gewoon beter kan zijn.

En zo werkt acceptatie vaak. Eerst in kleine stapjes, totdat het ineens hard gaat. Misschien ligt er vandaag nog geen kaas zonder koe in iedere keuken en bakken we nog niet overal koekjes zonder palmolie. Maar als die alternatieven straks wél de norm worden, wordt de biotechrevolutie ineens heel tastbaar. En het liefst ook proefbaar.

In West-Brabant zit in ieder geval volop energie om die beweging te versnellen en ervoor te zorgen dat vernieuwers als The Protein Brewery en Revyve juist op hun thuisgrond kunnen doorgroeien. Heel veel dank aan de organisatie voor de uitnodiging en aan de DKG Groep voor de gastvrijheid. En vooral: complimenten aan alle ondernemers die niet alleen praten over verandering, maar haar elke dag proberen te realiseren.

Onze werelden liggen dichter bij elkaar dan je op het eerste gezicht misschien denkt. En juist op dat snijvlak valt nog veel samen te winnen.

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From ambition to action: financing the biotech solutions of tomorrow

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Last Thursday afternoon, professionals from across the Dutch biotech ecosystem gathered at De Kas in Woerden for the fifth edition of Biotech for a Future-Proof Planet. Entrepreneurs, investors, researchers, policy makers and ecosystem partners came together to discuss one of the most pressing questions facing the sector today: how do we finance the next generation of biotech plants, food and materials? Against a backdrop of growing international competition and rising political attention for the biotech sector, speakers and attendees explored what is necessary to move biotech from smart ideas all the way to market adoption. The conclusion was clear: building a future-proof planet requires action across the entire ecosystem.

Key players in one room

The afternoon kicked off with a warm welcome from Remco Hermans, board member of the Dutch Biotechnology Association (NBV), who highlighted the value of bringing together people from every corner of the biotech ecosystem – all needed to translate biotech innovation into societal impact.

Building on that message, hollandbio’s Wieteke set the scene by outlining the opportunities and challenges Dutch biotech faces. Around the world, governments and investors increasingly recognise biotech as a strategic technology capable of addressing major societal challenges, from healthcare and food security to sustainability and circularity. At the same time, international competition is intensifying, with the United States and China investing heavily to strengthen their biotech ecosystems.

Wieteke emphasised that biotech innovation depends on a strong and connected ecosystem. An ecosystem, after all, is only as strong as its weakest link. While important progress has been made in recent years, including improvements in GMO permitting procedures and the adoption of new genomic techniques legislation, significant challenges remain. Financing continues to be on top of the list for companies looking to scale.

The scale-up challenge

Next on stage was Willemijn van der Elst, Investment Manager Agrifood at Invest-NL. She offered the audience an early glimpse into Invest-NL’s ongoing biotech deep dives, which are helping shape the organisation’s future ambitions and strategy for strengthening the Dutch biotech ecosystem.

According to Willemijn, the Netherlands has all the ingredients to become a leading biotech hub, including strong science, innovative companies and growing political momentum. Yet scaling innovative companies remains challenging. Across biotech applications, Invest-NL identified five recurring bottlenecks: financing, infrastructure, market adoption, regulation and coordination across value chains.

Drawing on findings from the agrifood deep dive, she explained that reaching commercial scale ultimately requires companies to secure production capacity, build teams with the right expertise and find their first customers. Unlocking the sector’s full economic and societal potential therefore requires action from everyone involved. Governments, investors, companies, ecosystem partners and customers each have a role to play in creating the conditions for growth.

From scientific breakthrough to successful business

Providing the private investor perspective was Guillaume Baxter, Partner at Sofinnova. He reflected on the evolution of industrial biotech over the past decade. The good news, he noted, is that the technology is increasingly mature, talent pools are growing and markets are actively looking for future-proof solutions.

His key message to entrepreneurs was straightforward: scale should be earned, not assumed. Companies must demonstrate they can manufacture at scale, build experienced teams, develop a compelling value proposition and establish a clear route to profitability. Because ultimately, customers only buy products when they are better, cheaper or solve a real problem.

Built in Europe, sold abroad… and now coming home?

The entrepreneurial perspective came from Ferdinand Los, CEO of Hudson River Biotechnology. Through the story of his company, he illustrated how funding, regulation and market development come together in practice.

Although the company is based in the Netherlands, much of its early commercial success came from markets outside Europe. Because genome editing was effectively not an option in the EU, the company was forced to pursue opportunities abroad, while raising capital became increasingly challenging due to the lack of a viable regulatory pathway and limited investor confidence.

The recent adoption of the EU’s Regulation on new genomic techniques (NGT’s) is already changing the picture. As Ferdinand put it, the company received more enquiries from European customers in the past four months than in the previous four years combined. This surge in interest shows the potential impact of the NGT Regulation. However, its ultimate success will depend on how the framework is translated into workable rules over the next two years.

Nevertheless, regulation alone will not be enough. Europe also needs stronger value-chain collaboration and greater access to growth capital if it wants to remain competitive in the global biotech race.

We need bold moves to make progress

The event concluded with an interactive panel discussion featuring Willemijn, Guillaume and Ferdinand, moderated by Wieteke. Topics ranged from AI and talent development to regulation, public acceptance and Europe’s competitiveness in an increasingly global biotech landscape. Although perspectives differed, the speakers largely agreed on three things: Europe has the scientific foundations to succeed, regulation and financing need to better support innovators as they scale, and collaboration across the value chain will be essential to bring biotech solutions to market.

But the discussion also carried a clear warning: Europe cannot afford to continue at its current pace. As Guillaume put it: “If we do not act decisively now, Europe risks being left with little more than a future built on tourism and services. The foundations are there, but scientific excellence and ambitious strategies will mean little unless they are followed by bold decisions and rapid, coordinated action.”

The energy in the room showed that the Dutch biotech ecosystem is ready to play its part. Conversations continued long after the formal program ended, with attendees exchanging ideas, making new connections and exploring opportunities for collaboration. That willingness to work together remains one of the Dutch biotech sector’s greatest strengths. Now, the growing pressure to improve Europe’s competitiveness must create the momentum to break through old barriers, make bold moves and turn ambition into action. The potential is there, but the time to act is now.

Photos by Nils van Houts.

This event was made possible by ChemistryNL.

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Hollandbio welcomes Simon-Kucher as a new member

Hollandbio connects, represents and supports the Dutch biotech sector. With more than 290 members – from start-ups and scale-ups to established companies active in health, food and the biobased economy – we work together to strengthen the Dutch life sciences ecosystem. Today, we are pleased to welcome Simon-Kucher as our newest member. Simon-Kucher is a global consultancy focused on unlocking better growth through commercial strategy, pricing, market access, innovation, marketing, and sales.

“For over 40 years, we have been a trusted advisor to the life sciences industry, working with pharmaceutical and biotech companies at all stages of development to translate scientific innovation into sustainable commercial success. Our teams bring deep life sciences expertise and a holistic commercial perspective to critical decisions around asset and portfolio strategy, value optimization, launch, and commercial excellence.”

“With nearly 2,200 employees across 45 offices in 32 countries, Simon-Kucher has a strong global presence. Our life sciences practice includes over 450 professionals based in29 offices in Europe, the United States, Latin America, China, Japan, and the Middle East. This network enables us to combine global experience with deep local market knowledge, supporting international launch strategies and market-specific approaches in key markets such as the US.”

“By joining Hollandbio, we aim to deepen our connections within the Dutch biotech ecosystem and contribute to the dialogue on key commercial questions shaping the industry today. Key areas include commercialization and pricing strategy, evolving market access policies such as MFN, AI in healthcare, as well as partnering and transaction strategy, and commercial due diligence for biotech leaders and investors. We look forward to exchanging ideas with hollandbio members and being a trusted partner to Dutch innovators as they turn promising science into successful businesses and better outcomes for patients.”

Meet the leadership team:

  • Eline Hendriksen-Middelburg, Director specializing in pricing, market access, strategy and commercial excellence for pharma and biotech.
  • Greta Mitzam, Director specializing in strategy, pricing, and commercial excellence across consumer health, animal health, and medtech.
  • Dirk Kars, Senior Partner (supporting & advising the Life Sciences Amsterdam team, based in Cologne, Germany), specializing in market access strategies, international pricing, contracting, and marketing for pharma and biotech.

Learn more about Simon-Kucher and the rest of our team on: www.simon-kucher.com

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From wait and see to fund and lead: A roundtable on financing Europe’s biotech frontrunners

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On 14 September, hollandbio joined a diverse group of biotech leaders for a roundtable discussion with EIC President Michiel Scheffer. The conversation, hosted by biotech company Khondrion in Nijmegen, focused on a key question: how can Europe build the next generation of biotech frontrunners?

Khondrion is dedicated to developing treatments for mitochondrial diseases, a group of often fatal rare diseases that can manifest at a very young age and for which no treatment currently exists that can slow the underlying disease process or its progression. Frank Alsemgeest left the room in silence as he shared what this means for families like his own: his son Robbe passed away at the age of three due to a mitochondrial disease.

Founder Jan Smeitink has independently guided the company from an academic concept to Phase III clinical development, a rare achievement within the Dutch biotech ecosystem. Yet bringing this innovation through the final stages of development and ultimately to patients requires tens of millions of euros in additional funding.

For Khondrion and other translational biotech frontrunners, such funding is far from readily available, especially in Europe. The challenge concerns a rare disease within a largely unexplored therapeutic field, despite an undeniable medical need. Every step from laboratory to patient is uncharted territory and must be designed and validated from scratch, from animal models and biomarkers to clinical endpoints. These pioneers often find themselves trapped in a “circle of wait and see,” where public and private investors, as well as pharmaceutical companies, follow developments with great interest, while waiting for someone else to make the first move. In the meantime, precious time is lost.

The status quo is all too familiar: Europe excels at generating world-class scientific discoveries and start-ups, yet struggles to scale them and capture their economic and societal value. The reason is simple: almost every key condition for biotech innovation is better organised elsewhere in the world.

The roundtable, moderated by biotech pioneer Ronald Brus, focused on precisely this challenge: how can we ensure that biotech frontrunners succeed in Europe rather than seeking opportunities abroad? Such as in the United States, where capital is significantly more abundant and investors have a greater appetite for risk. Or in China, where development can move at remarkable speed and, for now, at a fraction of the cost. Or South Korea, which has deliberately rolled out the red carpet for biotech innovation and is currently reaping the rewards.

The discussion made one thing clear: there is no silver bullet. Success requires an integrated approach. This includes fostering a more entrepreneurial culture, better aligning existing funding instruments and conditions with the unique characteristics of biotech innovation, and unlocking greater pools of capital, including pension fund investments and more attractive conditions for European IPOs. Equally important are faster and simpler regulatory pathways and an attractive market environment. Several ongoing European initiatives, such as the Biotech Act and the Capital Markets Union, provide valuable opportunities to strengthen these critical framework conditions.

The European Innovation Council (EIC), through its broad range of funding instruments that biotech companies already rely on extensively, plays a pivotal role in this. However, it is essential that public investors, including the EIC and national institutions such as Invest-NL, align more closely with the realities and needs of translational biotech frontrunners. For example, by offering greater support for later development stages and by taking a broader view of private investors, they can play a crucial role in mobilising and unlocking the patient, long-term capital these companies require.

By creating the right conditions, Europe can give its translational biotech frontrunners the momentum they need to succeed and ensure that European patients are among the first to benefit from the treatments they and their loved ones have been waiting for for so long.

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Biotech voor het eerst in de Troonrede

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Historische mijlpaal voor de Nederlandse biotechsector tijdens Prinsjesdag: voor het eerst noemde ons staatshoofd biotechnologie expliciet in de Troonrede. Daarmee benadrukt de regering het belang van technologie en innovatie voor de toekomstige welvaart van Nederland én de rol van biotech als cruciale sector daarin.

Koning Willem-Alexander: zonder tech-investeringen raakt Nederland achterop

Koning Willem-Alexander schetste een duidelijke opdracht: zonder gerichte investeringen in technologie dreigt Nederland achterop te raken. Daarom wil het kabinet samen met bedrijven en kennisinstellingen werken aan een economie waarin innovatie sneller tot nieuwe bedrijvigheid leidt en waarin start-ups en gevestigde bedrijven elkaar versterken. Meer financieringsmogelijkheden, experimenteerruimte en investeringen in technologische doorbraken moeten ervoor zorgen dat nieuwe innovaties kunnen uitgroeien tot de economische motoren van morgen. Daarbij werkt het kabinet aan plannen voor een nationale investeringsinstelling en voor een speciale organisatie die zich richt op grensverleggende technologische doorbraken.

Toptalent voor cruciale sectoren als biotechnologie

Bij de economie van morgen hoort ook voldoende talent. In de Troonrede wees de koning expliciet op het belang van het aantrekken, opleiden en behouden van toptalent – van mbo en hbo tot de universiteiten – in cruciale sectoren als biotechnologie. Een mooie erkenning van een uitdaging die hollandbio namens de sector al langer onder de aandacht brengt.

Toekomstige welvaart vraagt om schonere industrie

De koning stelde dat toekomstige welvaart alleen denkbaar is met schonere industrieën en minder fossiele brandstoffen. Daar draagt biotech bij uitstek aan bij met biobased grondstoffen, schonere productieprocessen en alternatieven voor fossiele materialen. Dat vraagt wel om beleid waarmee innovatieve bedrijven kunnen opschalen en hun oplossingen op de markt kunnen brengen.

Biotech voor beter voedsel

Ook de vastgelopen stikstofaanpak blijft een topprioriteit voor landbouw, natuur en voedselvoorziening. Innovatie kan helpen de tegenstelling tussen landbouw en natuur te doorbreken, bijvoorbeeld met betere gewassen en nieuwe, duurzamere manieren om voedsel en ingrediënten te produceren. De erkenning van biotechnologie als cruciale sector is daarom van belang, maar het kabinet zal zich moeten inspannen om ook de toepassing ervan mogelijk te maken.

Toekomstbestendige zorg vraagt meer dan kostenbeheersing

De regering toonde zich bezorgd over het vooruitschuiven van de rekening, maar er is meer nodig dan kostenbeheersing om de zorg toekomstbestendig te maken. Nieuwe geneesmiddelen, vaccins, diagnostiek en behandelingen kunnen ziekte voorkomen, patiënten beter helpen en de druk op de zorg verminderen. Een kabinet dat meer nadruk wil leggen op gezondheid, zal dus ook moeten investeren in de innovaties die gezondheidswinst mogelijk maken. Dat de regering spreekt over onderhoud van het zorgstelsel en meer inzet op preventie, is dan ook een ontwikkeling die hollandbio met interesse volgt.

Politiek initiatief voor preventie

Ook volgen we nauwgezet het initiatief dat regeringspartij D66 afgelopen weekend nam. Bij monde van fractievoorzitter Jan Paternotte presenteerde de partij van de premier het voorstel voor gratis obesitasmedicatie, een gezondheids-APK en een Rijksvaccinatieprogramma voor ouderen (waarover afgelopen dagen al verder over werd doorgepraat). Het plan krijgt steun: “Het is zuur dat mensen met een kleine portemonnee misgrijpen”, aldus hoogleraar Liesbeth van Rossum. “Zoals het nu gaat, dreigt obesitasmedicatie elitegeneeskunde te worden.” Een toegankelijk zorgstelsel vraagt dan ook niet alleen om beheersing van kosten, maar ook om ruimte voor innovaties die ziekte voorkomen of gezondheidswinst opleveren. Preventie serieus nemen betekent ook innovaties toegankelijk maken voor de mensen die ze nodig hebben. Daar mogen we de politiek aan houden.

Van erkenning naar actie

Dat biotech voor het eerst expliciet wordt genoemd in de Troonrede, is een belangrijk signaal. Die erkenning moet nu worden omgezet in concrete actie. Na deze eerste indruk van Prinsjesdag 2026 analyseren we bij hollandbio de begrotingen en beleidsplannen verder en gaan we in gesprek met Kamerleden over de keuzes die nodig zijn om Nederland innovatiever, schoner en gezonder te maken.

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Hollandbio welcomes iProtics as a new member

Hollandbio connects, represents and supports the Dutch biotech sector. With more than 290 members – from start-ups and scale-ups to established companies active in health, food and the biobased economy – we work together to strengthen the Dutch life sciences ecosystem. Today, we are pleased to welcome iProtics as our newest member. iProtics is a Leiden University spin-off, founded in 2024, developing next-generation, highly selective immunoproteasome inhibitors for patients with hematological cancers.

The company’s lead program, IP074, is initially being developed for patients with double-refractory chronic lymphocytic leukemia (CLL). Although proteasome inhibition has demonstrated therapeutic potential in hematological malignancies, existing approaches can be limited by off-target effects and dose-limiting toxicities. iProtics is developing precision small molecules designed to selectively inhibit the immunoproteasome in malignant cells, with the ambition to improve the therapeutic window while preserving healthy tissue.

The company is now advancing IP074 towards GLP toxicology studies, an important milestone in assembling the non-clinical package for first-in-human development. iProtics combines expertise in immunoproteasome biology, translational pharmacology and drug development to pursue a differentiated treatment approach for patients with limited remaining therapeutic options.

While iProtics was founded in 2024, its founders have already been actively contributing to the Dutch biotech landscape for several years. Among other milestones, they won the Venture Challenge in 2022 and participated in the Take Off, BiotechBooster, Faculty of Impact and BioVenture Builder programs. These experiences have helped shape iProtics into a company that combines strong academic science with a practical, patient-focused development strategy.

“We are excited to join hollandbio and become an active part of its community,” says Elmer Maurits, co-founder of iProtics. “We look forward to connecting with fellow innovators, entrepreneurs, investors and service providers, not only to explore collaborations that can help advance IP074, but also to contribute to a stronger, more connected Dutch life-sciences ecosystem and support other emerging companies where we can.”

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Hollandbio opnieuw een Great place to work! 

Hollandbio is voor het derde jaar op rij uitgeroepen tot Great Place to Work! Daar zijn we natuurlijk supertrots op. Ons onderzoek laat zien dat onze medewerkers zich niet alleen als een vis in het water voelen bij hollandbio, maar er bovendien van overtuigd zijn dat ze met hun werk kunnen bijdragen aan een betere wereld. Dat motiveert, verbindt en geeft volop voldoening. “Ons fantastische team is de drijvende kracht achter hollandbio’s succes,” zegt hollandbio’s Annemiek. “De resultaten zien dat iedereen zich gewaardeerd voelt, veel autonomie ervaart, en betekenis vindt in zijn werk. Deze extra boost om het verschil te maken voor onze leden en hun slimme oplossingen is iets waar ik ontzettend trots op ben!”

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Hollandbio asks for more impact in Biotech Act Part I

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The EU Biotech Act offers Europe a unique opportunity to strengthen its position as a global biotech leader. To help ensure the Act delivers on that promise, hollandbio submitted feedback this summer on Part I of the Act to the European Commission. We believe Europe is right to recognise biotech as a strategic technology for our health, planet and prosperity. But in today’s geopolitical reality, closing the gap with other global biotech contenders requires more than good intentions. While the Act contains several promising initiatives, we urged policymakers to keep their eyes on the prize: more biotech impact. In our response, we ask the commission to extend the scope and ambition of the Act, align policy with industrial reality, match financing with funding gaps, maximise the Act’s positive impact and enable progress at EU level. Because only by addressing the full value chain, we believe Europe can ensure that biotech innovations are not only discovered here, but also deployed here – delivering impact for patients, consumers and the economy.

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Hollandbio welcomes DGr Pharma as a new member

Hollandbio connects, represents and supports the Dutch biotech sector. With more than 290 members – from start-ups and scale-ups to established companies active in health, food and the biobased economy – we work together to strengthen the Dutch life sciences ecosystem. Today, we are pleased to welcome DGr Pharma as our newest member. DGr Pharma, based in Breda, is an internationally operating consultancy and contract research organization, which leverages the expertise and experience of its highly-skilled, multi-disciplinary workforce to accelerate drug development. By joining hollandbio, they want to meet innovative companies and to help them bring their products to the market.

“Our unique concentration of multidisciplinary experts – combined with a direct and pragmatic approach – presents sponsors with flexible service options to cope with business and regulatory requirements. Another strength is the flat organizational structure of DGr Pharma which encourages direct communication. This culture empowers experts with direct involvement in the decision-making process and allows sponsors easy and fast access to their expertise. We have an extensive track record, especially in the areas of oncology and infectious diseases and helped to bring more than 30 molecules successfully to the clincic and some of them even to the market.”

“Our CMC, non-clinical and clinical consultants can support every step in your drug development program from lead selection up to Phase IIa clinical trials. Whether you want support to successfully convert your lead molecule to a pharmaceutical product, input on your development strategy, assistance in preparation of meetings with regulatory agencies, advice on a single study, or whether you want us to manage your entire program, we will help realize a fast and high-quality drug development process.”

“Besides our consultancy services, we offer GLP certified PK/TK data analysis according to OECD guidelines using in-house validated Phoenix WinNonlin and SAS routines for both non-clinical and clinical studies. Our expert PK/TK data analysts provide high quality data for both small biotech, as well as large pharma in compliance with regulatory (EU and US) requirements. We are proud to say that our analyses have never led to regulatory questions.”

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Hollandbio welcomes CiNTL Pharma as new member

Hollandbio connects, represents and supports the Dutch biotech sector. With more than 290 members – from start-ups and scale-ups to established companies active in health, food and the biobased economy – we work together to strengthen the Dutch life sciences ecosystem. Today, we are pleased to welcome CiNTL Pharma as our newest member.

Based in Utrecht, CiNTL Pharma is a data-driven contract research organization (CRO) that is rethinking how clinical research is conducted. By combining scientific expertise, advanced data capabilities and execution within a single integrated platform, the company supports biopharmaceutical innovators across a broad range of therapeutic areas and development phases.

As Europe’s first fully agentic, data-driven CRO, CiNTL Pharma brings innovative approaches to clinical development that can help accelerate the path from scientific discovery to patient impact. Their expertise in clinical research and data management further strengthens the Dutch and European life sciences ecosystem and contributes to a more efficient, innovation-driven clinical development landscape.

Yolanda Cabrera-Sybesma, CEO of CiNTL Pharma: “By joining hollandbio, we strengthen our commitment to the Dutch biotech sector and unlock unprecedented opportunities for sponsors seeking innovation-driven partners. Together, we’re redefining how clinical trials should be managed.”

We warmly welcome Yolanda, Agnes, Shuling and the entire CiNTL team to the hollandbio community!

For general inquiries, please contact us at info@cintlpharma.com

Direct contacts: